Chlorpromazine

A neuroleptic (antipsychotic) medication that works by affecting neurotransmitters in the brain.

Trihexyphenidyl

An anticholinergic medication that helps to reduce the extrapyramidal side effects (eps) often associated with chlorpromazine.

Treatment of acute and chronic schizophrenia

Management of severe behavioral disturbances

Control of nausea and vomiting (especially in cases where other antiemetics are ineffective)

Reduction of extrapyramidal symptoms caused by other antipsychotics

Chlorpromazine blocks dopamine receptors in the brain, reducing psychotic symptoms. Trihexyphenidyl counteracts the extrapyramidal side effects (e.g., tremor, rigidity, akathisia) caused by dopamine blockade by inhibiting the action of acetylcholine.

Store at room temperature away from light and moisture. Keep out of reach of children. Discard any unused medication as per your pharmacist's or doctor's instructions.

Dosage is determined by your doctor based on your individual needs and response to treatment. It should never be changed without consulting your doctor.

The medication is typically administered orally, with the dosage split over multiple daily administrations.

Always follow your doctor's instructions precisely regarding dosage and frequency.

Orthostatic hypotension (low blood pressure upon standing)

Drowsiness or sedation

Dry mouth

Constipation

Blurred vision

Photosensitivity (increased sensitivity to sunlight)

Weight gain

Neuroleptic malignant syndrome (rare but serious)

Cardiac arrhythmias (rare)

Alcohol Consumption

Avoid alcohol consumption as it can worsen drowsiness and other side effects.



While Driving or operating Machinery

Avoid driving or operating machinery until you know how this medication affects you. Drowsiness is a common side effect.



Pregnant & Breastfeeding Women

Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. The use of chlorpromazine and Trihexyphenidyl during pregnancy and breastfeeding should be carefully considered due to potential risks to the fetus or infant.



Children

Use in children should be strictly as per physician's recommendation; dosage and monitoring needs are different compared to adults.



Kidney

Patients with impaired kidney function may require dosage adjustments. Your doctor will assess your kidney function before and during treatment.



Liver

Patients with impaired liver function may require dosage adjustments. Your doctor will assess your liver function before and during treatment.

Physician's Desk Reference (PDR)

Manufacturer's product monograph (Consult for specific formulation details)

Relevant medical textbooks and journals (Your doctor will have access to this)