L-Asparaginase

L-Asparaginase is an enzyme that breaks down the amino acid asparagine.It is produced by certain bacteria or fungi and is used as a medication.Available formulations may include L-asparaginase derived from Escherichia coli (E. coli) or Erwinia chrysanthemi.

Acute lymphoblastic leukemia (ALL) in children and adults.

Sometimes used in combination with other chemotherapy drugs.

May be used as a maintenance therapy after initial treatment.

Celginase 10000iu Inj (L-Asparaginase) works by depleting asparagine from the body. This amino acid is essential for the growth and survival of some cancer cells, particularly ALL cells. By reducing asparagine levels, L-asparaginase can slow down or stop the growth of these cancer cells.

L-asparaginase is typically stored in a refrigerator at a specific temperature. It is important to follow the instructions provided by your healthcare provider or the pharmacy for proper storage and handling.

The dosage of L-asparaginase will vary depending on factors such as the type of cancer, the patient's age and weight, and their overall health.

It is usually given intravenously (into a vein) as an injection or infusion.

The frequency and duration of treatment will also be determined by your healthcare provider.

Nausea and vomiting

Diarrhea

Abdominal pain

Pancreatitis

Allergic reactions

Blood clotting problems

Liver damage

Alcohol Consumption

Consult your healthcare provider about alcohol consumption while taking L-asparaginase, as it can potentially interact with the medication or worsen side effects.



While Driving or Operating Machinery

L-asparaginase can cause drowsiness, fatigue, and dizziness. Avoid driving or operating machinery if you experience these side effects.



Pregnant & Breastfeeding Women

L-asparaginase should only be used during pregnancy if the potential benefit outweighs the potential risks to the developing baby. It's important to discuss this with your healthcare provider. It is unknown if L-asparaginase is passed into breast milk. Consult with your doctor before breastfeeding.



Children

L-asparaginase is often used to treat children with ALL. The dosage and administration will be adjusted based on the child's age, weight, and overall health.



Kidney

Kidney problems can affect the way L-asparaginase is processed by the body. It is essential to inform your healthcare provider about any existing kidney issues.



Liver

L-asparaginase can cause liver damage. Your healthcare provider will monitor your liver function during treatment.

National Cancer Institute (NCI) - L-asparaginase

Drugs.com - L-asparaginase

Mayo Clinic - L-asparaginase (Intravenous Route)