Carvedilol

A non-selective beta-blocker and alpha-blocker.

Ivabradine

A selective inhibitor of the if current in the sinoatrial node.

Note: This combination is not a first-line treatment and is typically used when other therapies haven't adequately controlled symptoms.

Treatment of stable chronic heart failure (when added to standard therapy including ACE inhibitors or ARBs and diuretics).

Reduction of cardiovascular morbidity and mortality in patients with stable chronic heart failure.

Carvedilol reduces heart rate and blood pressure by blocking both beta-adrenergic and alpha-adrenergic receptors. Ivabradine selectively inhibits the If current in the sinoatrial node, slowing the heart rate without significantly affecting contractility. The combination provides synergistic effects in managing chronic heart failure by reducing heart rate, blood pressure, and myocardial oxygen demand.

Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children. Follow the prescription instructions for proper disposal.

Dosage is determined by a physician based on individual patient needs and response to therapy.

Typically, both medications are started at low doses and titrated gradually to achieve optimal therapeutic effect.

Always follow your physician's prescribed dosage and administration schedule.

Visual disturbances (phosphenes – flashes of light)

Bradycardia (slow heart rate)

Hypotension (low blood pressure)

Dizziness

Fatigue

Headache

Nausea

Constipation

Peripheral edema (swelling in the extremities)

Alcohol Consumption

Alcohol may potentiate the hypotensive effects of both carvedilol and ivabradine. Limit or avoid alcohol consumption.



While Driving or operating Machinery

May cause dizziness or fatigue, affecting ability to drive or operate machinery. Avoid until you know how this medication affects you.



Pregnant & Breastfeeding Women

Use should be avoided during pregnancy and breastfeeding unless the potential benefits clearly outweigh the risks. Consult your physician immediately.



Children

Safety and efficacy not established in children. Not recommended for pediatric use.



Kidney

Dose adjustment may be necessary in patients with renal impairment. Consult your physician.



Liver

Dose adjustment may be necessary in patients with hepatic impairment. Consult your physician.

Consult your physician or pharmacist for detailed prescribing information and package inserts.

Refer to reputable medical databases and journals for further information on Carvedilol and Ivabradine.