Clonazepam

A benzodiazepine medication that acts as a central nervous system depressant.

Propranolol

A beta-blocker medication that slows down the heart rate and reduces blood pressure.

Treatment of panic disorder with or without agoraphobia (often used together, with Clonazepam addressing anxiety and Propranolol managing physical symptoms like tachycardia).

Management of social anxiety disorder (specific situations where both anxiety and physical symptoms are prominent).

Treatment of essential tremor (when tremor is significantly impacting daily life, with Propranolol addressing tremor and Clonazepam potentially managing accompanying anxiety).

Clonazepam enhances the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve impulses, reducing anxiety and promoting relaxation. Propranolol blocks the effects of adrenaline (epinephrine) and noradrenaline (norepinephrine) on the heart and blood vessels, thus lowering heart rate, blood pressure, and reducing tremor.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Dispose of unused medication properly as per instructions.

Dosage should be determined by a healthcare professional based on the individual's condition, response, and other health factors.

Medication should be taken as prescribed and never adjusted without consulting a doctor.

Do not abruptly discontinue the medication without medical supervision to avoid withdrawal symptoms.

Drowsiness, dizziness, fatigue

Confusion, impaired coordination

Nausea, vomiting

Dry mouth

Constipation

Low blood pressure

Bradycardia (slow heart rate)

Depression

Respiratory depression (rare but serious)

Alcohol Consumption

Avoid alcohol consumption as it can exacerbate the sedative effects of clonazepam and increase the risk of side effects.



While Driving or operating Machinery

Avoid driving or operating machinery until you know how this medication affects you. Drowsiness and impaired coordination are potential side effects.



Pregnant & Breastfeeding Women

Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding. The medication may pose risks to the fetus or infant.



Children

Use in children should only be under the strict supervision and guidance of a healthcare professional.



Kidney

Kidney impairment may alter the metabolism and excretion of the medications, necessitating dosage adjustments.



Liver

Liver impairment may alter the metabolism of the medications, necessitating dosage adjustments.

Package inserts for Clonazepam and Propranolol.

Physician's Desk Reference (PDR).

UpToDate (online medical resource)