Amikacin

An aminoglycoside antibiotic effective against gram-negative bacteria.

Cefepime

A cephalosporin antibiotic effective against a broad range of gram-negative and some gram-positive bacteria.

Treatment of serious infections caused by susceptible Gramnegative bacteria, particularly those resistant to other antibiotics.

Empiric treatment of febrile neutropenia (low white blood cell count with fever).

Treatment of hospitalacquired pneumonia (HAP) and ventilator-associated pneumonia (VAP).

Treatment of intraabdominal infections.

Treatment of complicated urinary tract infections (UTIs).

Amikacin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Their combined action provides broader coverage and potential synergy against resistant organisms.

Store at controlled room temperature (20°C to 25°C). Protect from light and moisture. Discard any unused portion after the expiry date.

Dosage is determined by the physician based on the severity of infection, patient's renal function, and susceptibility testing.

Amikacin and Cefepime are usually administered intravenously (IV) over a specified time.

The combination therapy requires careful monitoring of serum drug levels to prevent toxicity.

Nephrotoxicity (kidney damage): Increased creatinine levels, reduced urine output.

Ototoxicity (hearing damage): Tinnitus, hearing loss, vertigo.

Neurotoxicity: Seizures, peripheral neuropathy.

Hypersensitivity reactions: Rash, itching, hives, anaphylaxis.

Gastrointestinal disturbances: Nausea, vomiting, diarrhea.

Blood disorders: Leukopenia, thrombocytopenia.

Alcohol Consumption

Alcohol consumption should be discussed with your doctor. It may interact negatively with certain medications, though not directly with this combination.



While Driving or operating Machinery

Patients experiencing side effects like dizziness or vertigo should avoid driving or operating machinery.



Pregnant & Breastfeeding Women

Use only when clearly needed and under close medical supervision. Risk to the fetus or infant should be carefully weighed against the benefits of treatment.



Children

Dosage adjustments are necessary based on age and weight. Use should be guided by a physician experienced in pediatric care.



Kidney

Requires careful dose adjustment due to risk of nephrotoxicity. Regular monitoring of kidney function is essential.



Liver

Liver function should be monitored, especially in patients with pre-existing liver disease, though hepatotoxicity is less common with this drug combination.

Package inserts for Amikacin and Cefepime.

Physician's Desk Reference.

Relevant medical journals and clinical guidelines.