Sitagliptin: A DPP-4 inhibitor that helps the body produce more insulin when needed.

Metformin: A biguanide that helps lower blood sugar levels by reducing glucose production in the liver and improving insulin sensitivity.

Treatment of type 2 diabetes mellitus in adults, particularly those who haven't achieved adequate glycemic control with metformin alone.

May be used as initial combination therapy in certain patients.

Can be used as an addon therapy to other diabetes medications if needed.

Sitagliptin works by inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme that breaks down incretins. Incretins stimulate insulin release and suppress glucagon secretion. Metformin reduces hepatic glucose production, enhances insulin sensitivity, and improves glucose uptake by peripheral tissues. The combination provides a synergistic effect on blood glucose control.

Store at room temperature (20°C-25°C or 68°F-77°F). Protect from moisture.

Dosage should be determined by your doctor based on your individual needs and response to treatment.

Typically started at a lower dose and gradually increased as tolerated.

Take with food to reduce gastrointestinal side effects.

Hypoglycemia (low blood sugar) – especially if combined with other diabetes medications or if dose is too high

Lactic acidosis (a rare but serious complication, more likely in patients with kidney disease)

Nausea, vomiting, diarrhea

Headache

Upper respiratory tract infection

Allergic reactions (rash, itching, swelling)

Alcohol Consumption

Limit alcohol consumption as it can increase the risk of lactic acidosis and hypoglycemia.



While Driving or Operating Machinery

May cause dizziness or hypoglycemia, which can impair ability to drive or operate machinery.



Pregnant & Breastfeeding Women

Generally not recommended during pregnancy or breastfeeding. Discuss with your doctor.



Children

Not approved for use in children.



Kidney

Dosage adjustment is often necessary for patients with kidney impairment. Lactic acidosis risk is increased.



Liver

Caution is advised in patients with liver disease.

Your doctor's instructions and medication information leaflet.

The product monograph provided by the manufacturer.