Atracurium Besylate

Atracurium besylate is the active ingredient. It's a non-depolarizing neuromuscular blocking agent.The specific formulation may include other inactive ingredients (e.g., preservatives, stabilizers) which vary depending on the manufacturer and delivery method (e.g., injection). Always check the product labeling for a complete list.

Adjunctive medication during general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery.

Shortterm muscle relaxation during mechanical ventilation in the intensive care unit (ICU).

Artacil 50mg Inj 5ml (Atracurium Besylate) acts by competitively blocking the action of acetylcholine at the neuromuscular junction, leading to muscle relaxation. It's a non-depolarizing blocker, meaning it doesn't initially cause muscle fasciculations (twitching). It's metabolized primarily by Hoffman elimination (nonspecific ester hydrolysis) and less by hepatic metabolism, which contributes to its relatively short duration of action.

Store at controlled room temperature (20-25°C). Protect from light. Discard any unused portion. Consult the manufacturer's prescribing information for detailed storage guidelines specific to the formulation.

Dosage is individualized and determined by the anesthesiologist or critical care physician based on patient factors (e.g., age, weight, underlying medical conditions).

It is administered intravenously.

Administration requires close monitoring of vital signs and neuromuscular function.

Hypotension (low blood pressure)

Tachycardia (rapid heart rate)

Bronchospasm (constriction of the airways)

Postoperative muscle pain

Malignant hyperthermia (rare, but serious).

Allergic reactions (rare).

Alcohol Consumption

Avoid alcohol consumption as it can potentiate the effects of anesthetic agents, including atracurium.



Driving or operating Machinery

Do not drive or operate machinery after receiving atracurium as it causes muscle weakness and drowsiness.



Pregnant & Breastfeeding Women

Use only if the potential benefits outweigh the potential risks. Consult a healthcare professional.



Children

Dosage adjustment is necessary for children; atracurium should only be administered under the supervision of a healthcare professional.



Kidney

Renal impairment may prolong the effect of atracurium, but the effect is minor due to its Hoffman elimination.



Liver

Hepatic impairment may slightly prolong the effect of atracurium, but adjustments are usually not needed.

Manufacturer's prescribing information (package insert)

Reputable medical textbooks and journals (e.g., medical databases such as PubMed)