Amphotericin B

Amphotericin B is an antifungal medication that belongs to the polyene antibiotic class.It is available in various formulations, including intravenous (IV) injections, liposomal injections, and oral capsules.

Treatment of severe fungal infections, particularly those caused by Aspergillus, Candida, Blastomyces, Histoplasma, and Coccidioides species.

Can be used for systemic fungal infections affecting various organs, including lungs, brain, kidneys, and skin.

Amphocrit 50mg Inj (Amphotericin B) works by binding to ergosterol, a component of fungal cell membranes, leading to disruption of the membrane's integrity and ultimately cell death.

Amphotericin B should be stored at room temperature, away from moisture and direct sunlight. Protect from freezing.

Dosage and frequency of administration vary depending on the severity and location of the infection, as well as the patient's age and overall health.

Amphotericin B is typically administered intravenously by a healthcare professional.

The oral capsule formulation is only used in specific circumstances and requires careful monitoring.

Always follow your doctor's instructions for dosage and duration of treatment.

Fever, chills, and rigors (shaking)

Nausea, vomiting, and diarrhea

Kidney problems, including decreased urine output

Low blood potassium levels

Low blood magnesium levels

Liver damage

Anaphylaxis (severe allergic reaction)

Alcohol Consumption

Avoid alcohol consumption while taking Amphotericin B, as it can increase the risk of liver damage.



While Driving or Operating Machinery

Amphotericin B can cause dizziness and fatigue. Avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

Amphotericin B should be used during pregnancy only if the potential benefit outweighs the risk to the fetus. It is unknown if it passes into breast milk, so consult your doctor before breastfeeding.



Children

The safety and efficacy of Amphotericin B in children have not been fully established.



Kidney

Patients with kidney problems should be monitored closely while taking Amphotericin B, as it can further impair kidney function.



Liver

Patients with liver problems should also be monitored closely, as Amphotericin B can cause liver damage.

https://www.drugs.com/mtm/amphotericin-b.html

https://www.mayoclinic.org/drugs-supplements/amphotericin-b-injection-route/art-20384411

https://www.webmd.com/drugs/2/drug-13936/amphotericin-b-intravenous/details