Amitriptyline

A tricyclic antidepressant (tca) medication that works by balancing certain chemicals in the brain.

Methylcobalamin

A form of vitamin b12, essential for nerve function and the production of red blood cells.

Amitriptyline: Primarily prescribed for major depressive disorder, but also used for neuropathic pain (nerve pain), anxiety disorders, and migraines.

Methylcobalamin: Used to treat vitamin B12 deficiency, which can cause anemia, fatigue, and neurological problems.

0 Amitriptyline: Increases the levels of neurotransmitters like serotonin and norepinephrine in the brain, which helps improve mood and reduce anxiety.1 Methylcobalamin: Acts as a coenzyme in various metabolic processes, including the production of myelin, a protective sheath around nerve fibers.

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Store the medication at room temperature, away from moisture and heat. Keep it out of reach of children and pets.

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Do not flush unused medication down the toilet or drain. Dispose of it properly as per your healthcare provider's instructions.

The dosage and frequency of administration vary depending on the individual's condition and response to treatment. It is essential to follow your doctor's instructions carefully.

Amitriptyline is usually taken orally, once or twice daily, at bedtime. Methylcobalamin is also administered orally, but may be available in injectable forms as well.

It is important to note that this combination may not be available in all countries, and the exact formulation and dosages might vary depending on your location.

Other possible side effects: Urinary retention, sexual dysfunction, increased sweating, tremors.

Common side effects: Dry mouth, drowsiness, blurred vision, constipation, dizziness, weight gain.

Serious side effects: Seizures, irregular heartbeat, suicidal thoughts or behaviors, low blood pressure, confusion, hallucinations.

Alcohol Consumption

Alcohol can increase the drowsiness and dizziness associated with amitriptyline. It is best to avoid alcohol while taking this medication.



While Driving or operating Machinery

Amitriptyline can cause drowsiness and impair your judgment. Avoid driving or operating heavy machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

Amitriptyline is not recommended during pregnancy, especially during the first trimester. It can pass into breast milk, so talk to your doctor about potential risks and benefits.



Children

Amitriptyline is not typically prescribed for children due to safety concerns.



Kidney

Patients with kidney problems may need dose adjustments. Talk to your doctor if you have any concerns.



Liver

Patients with liver problems may need dose adjustments. Talk to your doctor if you have any concerns.

https://www.mayoclinic.org/drugs-supplements/amitriptyline-oral-route/description/drg-20067103

https://www.ncbi.nlm.nih.gov/pubmed/25601850

https://www.webmd.com/drugs/2/drug-15764-Amitriptyline+Oral.aspx