Isoniazid

An antibiotic that specifically targets mycobacterium tuberculosis, the bacteria responsible for tuberculosis (tb).

Rifampicin

Another antibiotic effective against mycobacterium tuberculosis and a broad range of other bacteria. it works by inhibiting bacterial rna synthesis.

Treatment of tuberculosis (TB), both active and latent.

Prophylaxis (prevention) of TB in individuals at high risk of infection.

Treatment of certain other mycobacterial infections (as prescribed by a doctor).

Isoniazid inhibits the synthesis of mycolic acids, essential components of the Mycobacterium tuberculosis cell wall. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing bacterial protein synthesis and thus bacterial growth. The combination provides synergistic antimicrobial effects, increasing efficacy and reducing the risk of resistance development.

Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication according to your doctor's or pharmacist's instructions.

Dosage will be determined by your doctor based on your age, weight, health condition, and the severity of the infection.

The medication is typically administered orally, usually once daily.

It is crucial to complete the entire course of treatment as prescribed, even if you feel better, to prevent drug resistance and ensure complete eradication of the bacteria.

Jaundice (yellowing of the skin or eyes)

Peripheral neuropathy (numbness or tingling in the extremities)

Nausea

Vomiting

Loss of appetite

Abdominal pain

Dark urine

Lightcolored stools

Fatigue

Weakness

Rash

Itching

Flulike symptoms

Alcohol Consumption

Alcohol consumption should be limited or avoided during treatment as it can increase the risk of liver damage.



While Driving or operating Machinery

May cause dizziness or drowsiness; avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Use only as directed by a doctor; it can cross the placenta and be excreted in breast milk. Risks and benefits should be carefully considered.



Children

Dosage is adjusted based on the child's age and weight; must be prescribed and monitored by a pediatrician.



Kidney

Dosage adjustments may be necessary for individuals with kidney impairment.



Liver

Regular liver function tests are usually recommended, especially for individuals with pre-existing liver conditions. This medication can cause liver damage, so it’s crucial to monitor liver health closely.

Your doctor or pharmacist

The medication package insert

Reputable medical websites (e.g., CDC, WHO)