Ethambutol

An anti-tuberculosis drug that inhibits mycobacterial cell wall synthesis.

Isoniazid

An anti-tuberculosis drug that inhibits mycolic acid synthesis.

Pyrazinamide

An anti-tuberculosis drug with a mechanism of action not fully understood, but effective in sterilizing acidic environments within tubercular granulomas.

Rifampicin

A broad-spectrum antibiotic that inhibits bacterial dna-dependent rna polymerase.

Treatment of pulmonary tuberculosis (TB)

Treatment of extrapulmonary tuberculosis (TB)

This combination therapy targets multiple stages of Mycobacterium tuberculosis growth and replication. Each drug acts on a different aspect of the bacterial cell, making it harder for the bacteria to develop resistance.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication after the expiry date.

Dosage is determined by the physician based on the patient's weight, age, and overall health.

The medication is typically taken orally, once daily, or as directed by the physician.

Treatment duration usually ranges from 6 to 9 months or longer depending on individual circumstances and response to treatment.

Nausea

Vomiting

Loss of appetite

Abdominal pain

Headache

Dizziness

Rash

Itching

Visual disturbances (Ethambutol)

Peripheral neuropathy (Isoniazid)

Liver dysfunction (all drugs)

Jaundice

Dark urine

Alcohol Consumption

Alcohol consumption may increase the risk of liver damage. It's advisable to abstain from alcohol during treatment.



While Driving or operating Machinery

Patients should exercise caution as some side effects such as dizziness or visual disturbances may impair alertness.



Pregnant & Breastfeeding Women

Use during pregnancy and breastfeeding should be carefully considered and only under the guidance of a physician. The benefits must outweigh the potential risks to the fetus or infant.



Children

Dosage adjustments are necessary for children, based on weight and age.



Kidney

Kidney dysfunction may require dosage adjustments or monitoring. Inform the physician of any existing kidney problems.



Liver

Liver function tests are typically monitored during treatment due to potential hepatotoxicity.

Please consult your physician or pharmacist for complete prescribing information and references.