Dihydrochloride is the active ingredient in most betahistine formulations. it's a histamine h1 receptor agonist and h3 receptor antagonist.
Treatment of vertigo and dizziness associated with Ménière's disease.
Management of symptoms of peripheral vestibular disorders.
Zevert Sr 12mg Tab (Betahistine)'s mechanism isn't fully understood, but it's believed to act by improving blood flow in the inner ear, potentially through its effects on histamine receptors. The H1 agonism may dilate inner ear blood vessels, while H3 antagonism might modulate histamine release and neurotransmission in the vestibular system.
Store betahistine tablets in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Dosage should always be determined by a physician. It is usually started at a low dose and gradually increased as tolerated.
Typical dosages range from 8mg to 48mg per day, divided into several doses.
Follow your doctor’s instructions carefully regarding dosage and frequency.
Do not suddenly stop taking betahistine; consult your doctor before changing your dosage or stopping treatment.
Nausea
Headache
Stomach upset
Heartburn
Drowsiness
Gastritis (inflammation of the stomach lining)
Skin reactions (rare).
Avoid alcohol consumption while taking betahistine, as it may exacerbate drowsiness.
Caution is advised while driving or operating machinery, especially when starting treatment, due to the potential for drowsiness.
Use during pregnancy and breastfeeding should only be considered if the potential benefits outweigh the risks. Consult your doctor.
Safety and efficacy in children haven't been fully established.
Patients with kidney impairment may require dose adjustments. Consult your doctor.
Patients with liver impairment may require dose adjustments. Consult your doctor.
Please consult your doctor or pharmacist for detailed information and references specific to your situation.
