Sodium Valproate

Sodium valproate is the sodium salt of valproic acid.Different formulations may contain additional inactive ingredients such as fillers, binders, and coatings.

Treatment of epilepsy and seizure disorders (tonicclonic, absence, myoclonic, and mixed seizures)

Treatment of acute mania associated with bipolar disorder

Migraine prophylaxis (prevention)

The exact mechanism is not fully understood, but Valparin Chrono 400mg Tab (Sodium Valproate) is believed to increase the levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, thus reducing neuronal excitability and preventing seizures.

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Discard any unused medication as per instructions from a healthcare professional.

Dosage is determined by the physician based on the patient's age, weight, condition, and response to treatment.

Medication may be taken with or without food, as directed by the physician.

Different formulations (tablets, capsules, syrup) may have different administration methods.

Nausea, vomiting, and indigestion

Weight gain

Hair loss (alopecia)

Tremor

Drowsiness or dizziness

Increased liver enzymes (hepatotoxicity)

Pancreatitis (rare but serious)

Blood disorders (thrombocytopenia, leukopenia)

Cognitive impairment (in some cases)

Alcohol Consumption

Alcohol should be avoided or consumed in moderation while taking sodium valproate, as it can increase the risk of side effects.



While Driving or operating Machinery

Sodium valproate may cause drowsiness and dizziness. Avoid driving or operating machinery until you know how this medication affects you.



Pregnant & Breastfeeding Women

Sodium valproate is generally avoided during pregnancy and breastfeeding due to a high risk of birth defects. Consult your physician immediately if you become pregnant or plan to become pregnant while on this medication.



Children

Dosage and monitoring are crucial for children; a physician must determine the appropriate dose.



Kidney

Kidney impairment may require dosage adjustments.



Liver

Liver function tests are crucial. Liver problems can develop in some patients, necessitating close monitoring.

Your Physician's Instructions

Prescribing Information from Pharmaceutical Companies (check your specific brand)

UpToDate (a reputable medical information resource, subscription required for full access)

MedlinePlus (National Library of Medicine)