A sulfonylurea drug that stimulates the pancreas to release more insulin.
A biguanide that improves insulin sensitivity and reduces glucose production by the liver.
A thiazolidinedione (tzd) that improves insulin sensitivity by increasing the body's response to insulin.
Type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels.
Used in patients with inadequate glycemic control despite maximal tolerated doses of Metformin alone or another oral hypoglycemic agent.
This combination medication works through three distinct mechanisms to lower blood glucose levels. Glimepiride stimulates insulin release from the pancreas. Metformin enhances insulin sensitivity and reduces hepatic glucose production. Pioglitazone improves insulin sensitivity at the cellular level, increasing glucose uptake and utilization.
Store at room temperature (below 25°C). Protect from moisture and light. Keep out of reach of children.
Dosage should be determined by a healthcare professional based on individual needs and response to therapy.
Typically started at a lower dose and gradually increased as needed, always under medical supervision.
Take with or without food, but follow your doctor’s instructions precisely.
Hypoglycemia (low blood sugar): Symptoms include sweating, trembling, dizziness, confusion, and rapid heartbeat.
Liver function abnormalities (rare but serious with pioglitazone – requires monitoring)
Gastrointestinal upset (nausea, vomiting, diarrhea)
Weight gain (especially with pioglitazone)
Fluid retention
Allergic reactions (rash, itching, swelling)
Alcohol can increase the risk of hypoglycemia and should be consumed in moderation or avoided entirely, especially in patients with impaired liver function.
Hypoglycemia can impair judgment and reaction time. Avoid driving or operating machinery if you experience hypoglycemia.
Use during pregnancy and breastfeeding should be carefully considered and only under the supervision of a physician. Glimepiride is generally avoided during pregnancy. Consult your doctor before using this medicine.
Generally not recommended for use in children.
Metformin can accumulate in patients with kidney disease, increasing the risk of lactic acidosis. Renal function should be monitored regularly.
Pioglitazone can cause liver damage; liver function tests should be performed regularly.
Consult your physician or pharmacist for complete information. Refer to the official product monograph for detailed information about this medication.
Relevant medical journals and databases (mention specific journals if used).
