A sulfonylurea drug that stimulates the pancreas to release more insulin.
A biguanide that improves insulin sensitivity and reduces glucose production by the liver.
A thiazolidinedione (tzd) that improves insulin sensitivity by acting on cells' receptors.
Type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels.
Used in patients with inadequate glycemic control on metformin alone or other oral hypoglycemics.
This combination medication works through three distinct mechanisms to lower blood glucose levels. Glimepiride increases insulin secretion from the pancreas. Metformin decreases hepatic glucose production and improves insulin sensitivity in peripheral tissues. Pioglitazone enhances insulin sensitivity in muscle, fat, and liver cells. The combined effect leads to improved glycemic control.
Store at room temperature (below 25°C), in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Dosage should be determined by a physician based on individual needs and response.
Typically started at a low dose and gradually increased as needed.
Always take medication as prescribed; do not adjust dose without consulting doctor.
Hypoglycemia (low blood sugar): Symptoms may include dizziness, sweating, trembling, confusion.
Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal pain.
Weight gain
Fluid retention
Liver problems (rare but serious)
Allergic reactions (rash, itching, swelling).
Alcohol can increase the risk of hypoglycemia and should be consumed in moderation or avoided.
Hypoglycemia can impair cognitive function and reaction time. Avoid driving or operating machinery if experiencing hypoglycemic symptoms.
Generally not recommended during pregnancy or breastfeeding. Consult with doctor for alternatives.
Not typically recommended for children.
May need dosage adjustment or contraindicated in patients with severe kidney disease due to increased risk of lactic acidosis.
Requires careful monitoring due to potential for liver damage. Regular liver function tests may be needed.
Consult your physician or pharmacist for detailed information and references specific to your situation.
Package insert of the specific medication brand.
