Mesna

Is the active ingredient. formulations may include inactive ingredients such as sodium hydroxide for ph adjustment.

Prevention of hemorrhagic cystitis (bladder inflammation) caused by ifosfamide or cyclophosphamide chemotherapy.

Treatment of urotoxicity associated with ifosfamide or cyclophosphamide.

Mesna 200mg Inj (Mesna) acts as a sulfhydryl compound. It protects the bladder lining by binding to and inactivating the toxic metabolites of ifosfamide and cyclophosphamide, namely acrolein, which is the primary cause of hemorrhagic cystitis. Essentially, it acts as a scavenger of these harmful byproducts.

Store at room temperature, protect from light and moisture. Discard any unused portion after the expiry date.

Dosage is determined by the physician based on the patient's weight, condition, and the dose of ifosfamide or cyclophosphamide being administered.

It's typically given intravenously (IV) as an infusion or injection concurrent with or immediately following ifosfamide or cyclophosphamide administration.

Specific instructions will be provided by the healthcare professional.

Nausea

Vomiting

Diarrhea

Hypotension (low blood pressure)

Allergic reactions (rash, itching, swelling)

Injection site reactions (pain, redness, swelling)

Alcohol Consumption

The interaction between mesna and alcohol is generally not well-documented. Consult your doctor.



While Driving or operating Machinery

Mesna may cause drowsiness or dizziness in some individuals, therefore avoid driving or operating machinery until you know how mesna affects you.



Pregnant & Breastfeeding Women

Use during pregnancy and breastfeeding should only occur if the benefits outweigh the potential risks. Consult your doctor.



Children

Dosage should be adjusted based on the child's weight and condition. Prescriber must carefully evaluate the risk-benefit.



Kidney

Patients with kidney impairment may require dosage adjustment. Renal function should be monitored.



Liver

Liver function should be monitored. Significant liver impairment may require dosage adjustment or contraindication.

Consult your physician or pharmacist for detailed information and always refer to the official drug prescribing information.

Specific drug databases and medical journals should be referenced for further detailed information.