Lubiprostone is the active ingredient in medications like Amitiza and Plenvu.It is a chloride channel activator, specifically targeting the type 2 chloride channel in the gut.
Chronic idiopathic constipation (CIC) in adults.
Irritable bowel syndrome with constipation (IBSC) in adults.
Lubowel 8mg Tab (Lubiprostone) works by increasing fluid secretion in the intestines, which softens the stool and makes it easier to pass. It does this by activating type 2 chloride channels in the gut, leading to increased fluid and electrolyte secretion into the gut lumen.
Store Lubiprostone at room temperature, between 68°F and 77°F (20°C and 25°C). Protect from light and moisture.
The usual starting dose for CIC is 8 mcg once daily. It can be increased to 24 mcg once daily if needed.
For IBS-C, the usual dose is 24 mcg once daily.
Lubiprostone is taken orally, with or without food.
Other possible side effects include: abdominal pain, nausea, headache, fatigue, flatulence, vomiting, dizziness.
No specific information on alcohol consumption and Lubiprostone interactions is available. However, it's always best to consult your doctor about potential interactions with medications and alcohol.
Lubiprostone may cause dizziness or fatigue. Therefore, you should avoid driving or operating machinery until you know how it affects you.
Lubiprostone is a pregnancy category C drug, which means that it may be harmful to the fetus. It is not recommended for pregnant women unless the potential benefit outweighs the risk. It is also not known if Lubiprostone passes into breast milk. Consult your doctor before taking Lubiprostone if you are pregnant or breastfeeding.
Lubiprostone is not approved for use in children.
No dosage adjustment is usually required for people with kidney disease.
Lubiprostone should be used with caution in people with severe liver disease.
https://www.amitiza.com/
https://www.plenvu.com/
https://www.ncbi.nlm.nih.gov/pubmed/
