Gentamicin

Sulfate is the active ingredient in gentamicin formulations. it's an aminoglycoside antibiotic.

Treatment of serious infections caused by susceptible gramnegative bacteria (e.g., E. coli, Pseudomonas aeruginosa, Klebsiella pneumoniae).

Treatment of certain grampositive bacterial infections, often in combination with other antibiotics.

Treatment of bacterial endocarditis (infection of the heart valves).

Treatment of serious infections in patients with compromised immune systems.

Genta Inj 20ml (Gentamicin) binds to the 30S ribosomal subunit of bacteria, inhibiting protein synthesis and ultimately leading to bacterial cell death. This action is bactericidal (kills bacteria).

Store at room temperature, away from direct sunlight and moisture. Protect from freezing. Discard any unused portion after the expiry date.

Dosage is determined by the severity of the infection, patient's weight and kidney function.

Gentamicin is typically administered intravenously (IV) or intramuscularly (IM).

Dosage and frequency will be prescribed by a doctor and should be followed exactly.

The duration of treatment varies depending on the infection and patient's response.

Kidney damage (nephrotoxicity): This is a serious potential side effect and requires monitoring of kidney function.

Hearing loss (ototoxicity): Can range from temporary to permanent, affecting both balance and hearing.

Nausea and vomiting.

Allergic reactions (rash, itching, swelling).

Muscle weakness.

Numbness or tingling in the extremities.

Alcohol Consumption

Alcohol consumption should be discussed with your doctor, as it can potentially exacerbate side effects or interact with other medications.



While Driving or Operating Machinery

Gentamicin can cause dizziness or vertigo. Avoid driving or operating machinery if you experience these symptoms.



Pregnant & Breastfeeding Women

Use during pregnancy and breastfeeding should only be considered if the potential benefits outweigh the risks to the mother and child. Consult your doctor.



Children

Dosage should be adjusted based on the child's weight and kidney function. Close monitoring is crucial.



Kidney

Gentamicin is nephrotoxic, meaning it can damage the kidneys. Kidney function needs to be monitored closely, especially in patients with pre-existing kidney disease.



Liver

While primarily nephrotoxic, liver function may also need to be monitored, especially with prolonged use.

Physician's Desk Reference (PDR)

Micromedex

Relevant medical journals and clinical guidelines (specific references omitted for brevity)