Is the active ingredient.
Treatment of metastatic melanoma (skin cancer)
Treatment of Hodgkin's lymphoma (in combination with other chemotherapy drugs)
Treatment of soft tissue sarcomas (in combination with other chemotherapy drugs)
Arzi 1000mg Injection (Dacarbazine) is an alkylating agent. It works by damaging the DNA of cancer cells, preventing them from dividing and growing. The exact mechanism is complex and involves the formation of reactive metabolites that interfere with DNA replication and repair.
Store Dacarbazine at room temperature (20-25°C) away from light and moisture. Protect from freezing. Handle with appropriate precautions to avoid skin contact. Dispose of unused medication properly according to your healthcare provider's instructions.
Dosage is determined by your doctor based on your individual health condition and response to treatment.
It is typically administered intravenously (IV) by a healthcare professional.
Specific dosage instructions will be provided by your oncologist.
Nausea and vomiting
Loss of appetite
Fatigue
Alopecia (hair loss)
Flulike symptoms
Liver toxicity (hepatotoxicity)
Kidney toxicity (nephrotoxicity)
Inflammation of the mucous membranes (mucositis)
Hypersensitivity reactions
Alcohol consumption may exacerbate side effects such as nausea and vomiting. Consult your doctor.
Dacarbazine can cause fatigue and other side effects that may impair your ability to drive or operate machinery. Avoid these activities if affected.
Dacarbazine is harmful to a developing fetus and should not be used during pregnancy. It's also not recommended during breastfeeding due to the risk of the drug passing into breast milk.
Dosage and administration in children differ significantly; it must be determined by a pediatric oncologist.
Kidney function should be monitored regularly as dacarbazine can be toxic to the kidneys.
Liver function should be monitored regularly as dacarbazine can be toxic to the liver.
Your oncologist
The prescribing information from the pharmaceutical company
Reputable medical websites such as the National Cancer Institute (NCI)
